mgsR [2017-8-11 16:0:3]

transcriptional regulator of a subset of the [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB] general stress regulon, required for protection against oxidative stress

locus: BSU24770

pI: 9.28

mw: 14.68 kDa

protein length: 126 aa

gene length: 378 bp

function: controls a subset of general stress genes

product: transcriptional regulator

essential: no

synonyms: yqgZ

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]

Gene

Coordinates: 2,564,026 → 2,564,406

The protein

Catalyzed reaction/ biological activity

• exerts a positive or negative effect on the expression of 53 or 18 stress genes, respectively [Pubmed|18643936]

Protein family

• arsC family (according to Swiss-Prot) Arsenate Reductase (ArsC) family, Spx subfamily

Paralogous protein(s)

• [protein|2C6386E9A63F410558D168798D077DF91590F454|Spx]

Modification

• [protein|6A38DAA96F7BBF31FD8A4018A8CA7A72F3C28F79|MgsR] is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress [Pubmed|22812682]

Structure

• [PDB|3L78] (from Streptococcus mutans, 42% identity)

Expression and Regulation

Operons

• genes: [gene|6A38DAA96F7BBF31FD8A4018A8CA7A72F3C28F79|mgsR]
  description: [Pubmed|18643936]

  sigma factors

  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|18643936], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]

  regulatory mechanism

  • [protein|6A38DAA96F7BBF31FD8A4018A8CA7A72F3C28F79|MgsR]: activation, in [regulon|6A38DAA96F7BBF31FD8A4018A8CA7A72F3C28F79|MgsR regulon]

  regulation

  • induced by stress ([protein|search|SigB]) [Pubmed|15805528,18643936]

  additional information

  • [protein|search|MgsR] is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress [PubMed|22812682]

Biological materials

Mutant

• MGNA-C476 (yqgZ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2474 NBRP B. subtilis, Japan]

References

• 18643936,12107147,15805528,18643936,22812682,22582280